Prokineticin receptor 1

PROKR1
Identifiers
Aliases	PROKR1, GPR73, GPR73a, PKR1, ZAQ, prokineticin receptor 1, PK-R1
External IDs	OMIM: 607122; MGI: 1929676; HomoloGene: 10968; GeneCards: PROKR1; OMA:PROKR1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	68,658,251 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	87,567,725 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; ganglionic eminence; ; appendix; ; pituitary gland; ; lactiferous gland; ; anterior pituitary; ; muscle layer of sigmoid colon; ; right adrenal gland; ; hypothalamus;
	Top expressed in
	lumbar spinal ganglion; ; internal carotid artery; ; external carotid artery; ; inner renal medulla; ; blood; ; epithelium of lens; ; ventricular zone; ; efferent ductule; ; human fetus; ; dermis;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; neuropeptide Y receptor activity; pancreatic polypeptide receptor activity; G protein-coupled receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane; integral component of plasma membrane;
Biological process	circadian rhythm; negative regulation of apoptotic process; signal transduction; neuropeptide signaling pathway; chemical synaptic transmission; feeding behavior; blood circulation; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10887
	58182
	ENSG00000169618
	ENSMUSG00000049409
	Q8TCW9
	Q9JKL1
	NM_138964
	NM_021381; NM_001355655
	NP_620414
	NP_067356; NP_001342584
	Wikidata
View/Edit Human	View/Edit Mouse

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Prokineticin receptor 1, also known as PKR₁, is a human protein encoded by the PROKR1 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169618 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049409 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PROKR1 prokineticin receptor 1".

Parker R, Liu M, Eyre HJ, et al. (2000). "Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6". Biochim. Biophys. Acta. 1491 (1–3): 369–75. doi:10.1016/s0167-4781(00)00023-3. PMID 10760605.
Lin DC, Bullock CM, Ehlert FJ, et al. (2002). "Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor". J. Biol. Chem. 277 (22): 19276–80. doi:10.1074/jbc.M202139200. PMID 11886876.
Masuda Y, Takatsu Y, Terao Y, et al. (2002). "Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors". Biochem. Biophys. Res. Commun. 293 (1): 396–402. doi:10.1016/S0006-291X(02)00239-5. PMID 12054613.
Soga T, Matsumoto S, Oda T, et al. (2003). "Molecular cloning and characterization of prokineticin receptors". Biochim. Biophys. Acta. 1579 (2–3): 173–9. doi:10.1016/S0167-4781(02)00546-8. PMID 12427552.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Battersby S, Critchley HO, Morgan K, et al. (2004). "Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle". J. Clin. Endocrinol. Metab. 89 (5): 2463–9. doi:10.1210/jc.2003-032012. PMID 15126578.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Pasquali D, Rossi V, Staibano S, et al. (2006). "The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy". Endocrinology. 147 (9): 4245–51. doi:10.1210/en.2006-0614. PMID 16763065.

External links

"Prokineticin Receptors: PKR₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2009-07-17. Retrieved 2008-12-09.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169618 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049409 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PROKR1 prokineticin receptor 1".

[1]

Prokineticin receptor 1

See also

References

Further reading

External links