- Heir to the Champion spark plug fortune
- Second cousin of Burn Notice (2007) actor Bruce Campbell.
- In early 2005, he took 13 months off from acting to circumnavigate the globe on a sailing trawler. He joined the crew of The Picton Castle which set sail from Nova Scotia to deliver charitable donations of school essentials, clothing and supplies throughout the South Pacific. The creators of 'the 4400' coped with his planned absence by having his character Jordan Collier assassinated.
- Has volunteered as an actor with the Young Storytellers Program.
- The character Billy Campbell on Melrose Place (1992) was named after him.
- He was the second choice for the role of Commander William Riker on Star Trek: The Next Generation (1987), but Jonathan Frakes won the part. However, he guest-starred as Captain Thadiun Okona in the episode The Outrageous Okona (1988), on 10 December 1988.
- Rick Sammler, Campbell's character on Once and Again (1999), was ranked #36 in TV Guide's list of the "50 Greatest TV Dads of All Time" [20 June 2004 issue].
- Is a rugby enthusiast, having played rugby with the Chicago Lions RFC, the Santa Monica Rugby Club, and the Las Vegas Rugby Club.
- Chosen by People magazine as one of the 50 most beautiful people in the world (2000)
- Parents divorced when he was two years old. He shuttled between his mother in Virginia and his father in Chicago.
- Wife, Anne, is from Norway. They have two children together.
- He and Stephen Lang appeared together in Gettysburg (1993) as Lt. Pitzer and Gen. Picket, respectively, and were both all set to play those same characters in the prequel, Gods and Generals (2003). However, a suitable actor could not be found to play lead character Gen. Thomas "Stonewall" Jackson, so Lang was given that role and Campbell stepped into the role of Picket.
- Attended Fork Union Military Academy.
- He has six half-siblings including David Campbell and John Campbell.
- Appeared in a high school production of "The Man Who Came to Dinner" and played Petruchio once in an outdoor production of "The Taming of the Shrew" at the Southern California Renaissance Faire.
- In Enough (2002), he is slapped eight times and punched eight times by Jennifer Lopez in the final fight.
- Of Clan Campbell.
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